Ophiocordyceps sinensis (Keera Jari/ Himalayan Viagra): Pharmacological properties and their therapeutic potential
Review Article
DOI:
https://doi.org/10.21276/pt.2025.v2.i4.4Keywords:
Ophiocordyceps sinensis, Keera Jari, Himalayan Viagra, Medicinal applications, Himalayan plateauAbstract
Ophiocordyceps sinensis (Keera jari), also known as caterpillar fungus, is a member of the Ophiocordycipitaceae family of fungi that parasitizes ghost moth larvae and produces a fruiting body valued as herbal medicine. Due to its numerous uses in the pharmaceutical and medical fields, Cordyceps species are commonly referred to as traditional Chinese medicine (TCM). Keera jari has been acknowledged in Nepal for many years, and in India it is known as ‘keera jari’ or ‘keera ghas.’ It is among the most promising therapeutic mushrooms in the world. People all throughout the world use the caterpillar fungus for its tremendous therapeutic properties. It grows between 3500 and 4500 meters above sea level on the upper Himalayan plateau. This review's goal is to gather information on Keera jari (Yarsagumba), including its history, cultivation, taxonomic traits, several medicinal applications, and phytochemical research that has been done thus far.
References
1. Shrestha B, Zhang W, Zhang Y, Liu X. What is the Chinese caterpillar fungus Ophiocordyceps sinensis (Ophiocordycipitaceae)? Mycology. 2010; 1(4): 228–236. https://doi.org/10.1080/21501203.2010.53679
Shrestha B. Diversity of Cordyceps fungi in Nepal. Nep J Sci Technol. 2011; 12: 103–110. https://doi.org/10.3126/njst.v12i0.6487
Winkler D. Cordyceps sinensis: A precious parasitic fungus infecting tibet. Field Mycology. 2010; 11:60–67. https://doi.org/10.1016/j.fldmyc.2010.04.009
Winkler D. Yartsa Gunbu (Cordyceps sinensis) and the fungal commodification of Tibet’s rural economy. Econ Bot. 2008; 62: 291–305. https://doi.org/10.1007/s12231-008-9038-3
Sen S, Karati D, Priyadarshini R, Dua TK, Paul P, Sahu R, Nandi G. Cordyceps sinensis (yarsagumba): Pharmacological properties of a mushroom. Pharmacol Res Mod Chin Med. 2023; 8:100294. https://doi.org/10.1016/j.prmcm.2023.100294
Maity D. A study on ethnomedicinal uses of yartshagumba, Cordyceps sinensis (berk.) sacc. (cordycipitaceae), by the trinal communities of North Sikkim and its conservation. Explor. Anim Med Res. 2013; 3, 95–101.
Olatunji OJ, Tang J, Tola A, Auberon F, Oluwaniyi O, and Ouyang Z. The genus Cordyceps: an extensive review of its traditional uses, phytochemistry and pharmacology. Fitoterapia. 2018; 129, 293–316. https://doi.org/10.1016/j. fitote.2018.05.010.
Baral B, ShresthaB, and Teixeira De Silva, JA. A review of Chinese Cordyceps with special reference to Nepal, focusing on conservation. Environ Exp Biol. 2015; 13, 61–73.
Paul FC, Nigel LHJ, Norbert M, Lungten N, Tashi S, Phurba L. Steps towards sustainable harvest of Ophiocordyceps sinensis in Bhutan. Biodiver Cons. 2009; 18: 2263–2281. https://ui.adsabs.harvard.edu/link_gateway/2009BiCon..18.2263C/doi:10.1007/s10531-009-9587-5
Wu P, Tao Z, Liu H, Jiang G, Ma C, Wang, C. Effects of heat on the biological activity of wild Cordyceps sinensis. J Trad Chin Med Sci.2015; 2, 32–38. https://doi.org/10.1016/j.jtcms.2014.12.005.
Jia-Shi Zhu, MD, Ph.D. and James Rippe, M.D. Presented at the American Physiological Society's (APS) annual scientific conference, Experimental Biology 2024;, April 17-21, 2004, Washington, D.C.
Shrestha UB, Bawa KS. Trade, harvest, and conservation of caterpillar fungus (Ophiocordyceps sinensis) in the Himalayas. Biol Conserv. 2013;159: 514–520. https://doi.org/10.1016/j.biocon.2012.10.032
Sharma S. Trade of Cordyceps sinensis from high altitudes of the Indian Himalaya: conservation and biotechnological priorities. Curr Sci. 2004; 86: 1614-1619.
Garbyal SS, Aggarwal KK, Babu CR. 2004. Impact of Cordyceps sinensis in the rural economy of interior villages of Dharchula subdivision of Kumaon Himalayas and its implications in the society. Indian J Trad Knowledge. 2004; 3: 182–186.
Holliday, J, and MP. Cleaver. Medicinal value of the Caterpillar fungi species of the genus Cordyceps (fr.) link (Ascomycetes). a review. Int J Med Mushrooms. 2008;10(3): 219-234. https://doi.org/10.1615/IntJMedMushr.v10.i3.30
Zhou X, Gong Z, Su Y. Cordyceps fungi: natural products, pharmacological functions and developmental products. J Pharm Pharmacol. 2009; 61: 279–91. https://doi.org/10.1211/jpp/61.03.0002
Miller RA. The Cordyceps sinensis medicinal mushroom. 2009; Nexus, pp. 23–28.
Negi CS, Korang PR, Ghinga HS. Yar tsa Gumba (Cordyceps sinensis): a call for its sustainable exploitation. Int J Sustain Dev World Ecol. 2006; 13: 165-172. https://doi.org/10.1080/13504500609469669.
Negi CS. Declining transhumance and subtle changes in livelihood patterns and biodiversity in the Kumaon Himalaya. Mt Res Dev. 2007; 27: 114-118. https://doi.org/10.1659/mrd.0818.
Liu, Y, Wang, J, Wang W, Zhang H, Zhang X, and Han C. The chemical constituents and pharmacological actions of Cordyceps sinensis. 2015; Evid Based Complement Alternat Med. 2015, 575063. https://doi.org/10.1155/2015/575063.
Shashidhar MG, Giridhar P, Udaya Sankar K, and Manohar B. Bioactive principles from Cordyceps sinensis: a potent food supplement – a review. J Funct Foods. 2013; 5, 1013–1030. https://doi.org/10.1016/j.jff.2013.04.018.
Lu, RL, Luo, FF, Hu FL, Huang, B, Li CR and Bao GH. Identification and production of a novel natural pigment, cordycepoid A, from Cordyceps bifusispora. Appl Microbiol Biotechnol. 2013; 97: 6241–6249. https://doi.org/10.1007/s00253-013-4966-y.
Chen KT, Su CH, Chang HC and Huang JY. Differentiation of genuines and counterfeits of Cordyceps species using random amplified polymorphic DNA. Planta Medica. 1998; 64: 451-453.
Negi CS. Declining transhumance and subtle changes in livelihood patterns and biodiversity in the Kumaon Himalaya. Mt Res Dev. 2007; 27: 114–118. https://doi.org/10.1659/mrd.0818
Olsen CS, Larsen HO. Alpine medicinal plant trade and Himalayan mountain livelihood strategies. Geograp J. 2003; 169: 243-254. https://10.1111/1475-4959.00088.
Bhandari AK, Negi JS, Bisht VK, Singh N, Sundriyal RC. Cordyceps sinensis: fungus inhabiting the Himalayas and a source of income. Curr Sci. 2012; 103(8), 876. http://indianmedicine.eldoc.ub.rug.nl/id/eprint/64186
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